Officers and ambulance staff attended the scene.
Following attendance at the scene, two females and two males were deceased at the scene. A further male,Jake Davison, was also deceased at the scene. All are believed to have died from gunshot wounds.
Another female treated at the scene for gunshot wounds, died a short time later in hospital.
The area has been cordoned off and police are not looking for anyone else in connection with the incident.
Investigations are continuing into the incident and disruption to the road network in the Keyham will remain throughout the night.
Police continue to ask any members of the public with mobile phone footage of the immediate aftermath of the incident not to post this on social media platforms and to respect those families who have lost loved ones this evening.