Police were called to a residential address in Mount Pleasant Lane, E5 at 11.29pm on Friday, 24 January following reports of a disturbance.
Officers and London Ambulance Service attended.
A man, believed to be a Polish national aged in his 60s, was found with stab injuries inside the property.
Despite the efforts of emergency services, the man was declared dead a short time later. While officers believe they know his identity, they await formal identification.
A post-mortem examination will be scheduled in due course.
A 22-year-old man was arrested at the scene on suspicion of murder and charged as above.
The two men are believed to have been known to each other, but not related.